3 ap — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T1982	3-AP	NSC663249,Triapine,PAN-811,OCX191	DNA/RNA Synthesis
	3-AP (Triapine) is a novel inhibitor of the M2 subunit of ribonucleotide reductase (RR).		DNA/RNA Synthesis
T22730	DL-AP3		GluR
	DL-AP3 is a competitive group I metabotropic glutamate receptor antagonist and inhibitor of phosphoserine phosphatase.		GluR
T13549	AP1867-3-(aminoethoxy)		Others
	AP1867-3-(aminoethoxy) is a synthetic ligand for FKBP and can be used in the synthesis of PROTAC FKBP12 F36V degrader.		Others
T10384	Farudodstat	ASLAN003	Apoptosis , Dehydrogenase , DNA/RNA Synthesis
	Farudodstat (ASLAN003) is an orally active and potent inhibitor of DHODH (Human Dihydroorotate Dehydrogenase) with antitumor activity. It has the potential to be a first-in-class candidate in AML.		Apoptosis , Dehydrogenase , DNA/RNA Synthesis
T40838	20-O-Demethyl-AP3	20-O-Demethyl-AP3
	20-O-Demethyl-AP3 is a secondary metabolite derived from Ansamitocin P-3, and Ansamitocin P-3 is a macrocyclic antitumor antibiotic exerting its therapeutic effects by inhibiting microtubules.
T39830	L-AP3	3-Phosphono-L-alanine,L-AP3
	L-AP3 is a potent antagonist of metabotropic glutamate receptor (mGluR), demonstrating inhibitory effects on D-phosphoserine and L-phosphoserine with IC50 values of 368 μM and 2087 μM, respectively.
T77570	AP-C2		PKA
	AP-C2 is a potent small molecule guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) inhibitor with a pIC50 of 5.2 for cGKII.		PKA
T60500	AP-C5		Parasite
	AP-C5 is a compound with selective inhibition of guanosine 3',5' cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII), with a Pic50 value of 7.2 for cGMP, and can be used in the study of diarrheal diseases.		Parasite
T6981	1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid	Nudifloric Acid	Others
	1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid (Nudifloric Acid) is from Cordyceps bassiana. Nudifloric Acid targets to block AP-1-mediated luciferase activity, implying it has an anti-inflammatory function.		Others
TN1237	3-O-Methylgallic acid	3,4-Dihydroxy-5-methoxybenzoic acid	Apoptosis , NF-κB , OCT , DNA/RNA Synthesis , STAT
	3-O-Methylgallic acid (3,4-Dihydroxy-5-methoxybenzoic acid) reduces cell proliferation in Caco-2 cells(IC50 = 24.1 μM) more effectively than anthocyanins and may offer protection against colon cancer after its formation ...		Apoptosis , NF-κB , OCT , DNA/RNA Synthesis , STAT
T5416	T-5224		MMP
	T-5224 is a transcription factor c-Fos/AP-1 inhibitor, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors.		MMP
TN1880	Lucidenic acid B	Lucidenicacid B	Apoptosis , Caspase
	Lucidenic acid B (Lucidenicacid B), a natural compound extracted from Ganoderma lucidum, induces activation of caspase-9 and caspase-3 and cleavage of PARP, which can induce apoptosis in human leukemia cells through mito...		Apoptosis , Caspase
T6456	CRT0044876	NSC 69877,7-NO2-ICA,NSC 69877,7-Nitroindole-2-Carboxylic Acid	DNA/RNA Synthesis
	CRT0044876 (7-NO2-ICA) is a potent and selective APE1 inhibitor with IC50 of ~3 μM.		DNA/RNA Synthesis
T3S0737	Flavokawain A	Flavokavain A	Apoptosis , p38 MAPK
	NSC-37445 has anti-tumor activity, such as inhibits growth of bladder tumor cells in a nude mice model , prevents the recurrence and progression of non-muscle-invasive urothelial cell carcinoma. NSC-37445 can significant...		Apoptosis , p38 MAPK
T82990	AP-C4
	AP-C4 is a selective inhibitor targeting guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII), exhibiting a pIC50 value of 5.2. Conversely, AP-C3 does not inhibit cGKII-mediated anion secretion...
T82991	AP-C3
	AP-C3 is a potent inhibitor of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII), exhibiting a pIC50 value of 6.3 and demonstrating only weak inhibition of cGKII-dependent anion secretion [1...
T82989	AP-C6
	AP-C6 is a potent inhibitor of guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII), exhibiting a pIC50 of 6.5. It inhibits human cGKII activity in vitro in a concentration-dependent manner and...
T35943	15(S)-HpETE
	15(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of 15-lipoxygenase (15-LO) on arachidonic acid. It is either metabolized to 14,15-leukotriene A4 [1] or reduced to 15(S)-HETE by ...